Partner up to invade

Partner up to invade

Partner up to invade A secretory complex and a cytoskeletal polarity protein cooperate to make tumor cells more invasive, according to new work from Sakurai-Yageta et al. To burrow into nearby tissue, tumor cells create membrane protrusions called invadopodia. Within invadopodia, vesicles accumulate that contain metalloproteinase enzymes needed to degrade the extracellular matrix. Because a sec...

A way to invade

Overexpression of the ErbB2 (Her2/neu) receptor tyrosine kinase is implicated in the induction and progression of many different types of human cancers. It is particularly frequent in breast cancer, where up to 25% of patients overexpress ErbB2. The ErbB2-positive cancers exhibit extremely malignant and invasive behavior, which is associated with increased disease recurrence and worsened progno...

HIV self-testing to scale up couples and partner testing.

HIV self-testing is benefi ting from substantial investment in implementation research from major donors and rapid development of evidence-based policy and practice. The reason for such excitement around HIV self-testing is three-fold. First, diagnosing 90% of all people with HIV—the fi rst step of the UN’s goal to end the HIV epidemic by 2030—will require a substantial increase in testing serv...

Not to invade: a better strategy?

Ending up with the right partner.